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Raman Rxn-45 probe

The ultimate in compatibility for bioprocess manufacturing

Product picture Raman Rxn-45 probe side view aiming right Product picture Raman Rxn-45 probe installed in a stainless steel bioreactor Product picture Raman Rxn-45 probe side view aiming up right Product picture Raman Rxn-45 probe side view aiming down right
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Product picture Raman Rxn-45 probe installed in a stainless steel bioreactor
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Raman Rxn-45 probe

The ultimate in compatibility for bioprocess manufacturing

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Benefits

  • Measures multiple components in real-time for automated 24/7 process feedback
  • Provides long-term measurement stability
  • Offers a suitable surface finish for cGMP manufacturing
  • Provides compatibility with industry standard bioreactor side ports and sensor housings
  • Offers the flexibility of being installed in development and production reactors
  • Reduces sterilization and cleaning burdens with CIP/SIP standard compatibility
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Integrated technologies

Raman spectroscopy - advanced optical analysis technology

Services and resources

Product Support Product documentation, troubleshooting articles, device details and more.
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Raman Rxn-45 probe

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Manufacturer's warranty

Engineered for confidence

Our instruments are designed for long‑lasting performance, precise measurement, and dependable operation in demanding industrial environments. Each product includes a standard manufacturer’s warranty that reflects our commitment to quality and to the trust you place in our solutions.

Should a warranty case occur, the device will be assessed and the applicable remedy will be provided in line with the warranty terms – helping ensure a reliable and efficient resolution and supporting continued operation of your measurement point.

Request for extended warranty

If you require extended warranty coverage, simply contact your local Endress+Hauser representative. Our experts will advise you on the available options to match your application and risk profile, helping you protect your investment, reduce unexpected repair costs, and ensure reliable long‑term operation beyond the manufacturer's warranty period.

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Warranty terms apply

The manufacturer's warranty and extended warranty are subject to specific conditions. For full details, please refer to the locally applicable General Terms and Conditions (GTC), which can be found on the respective country page of our website.

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Right‑first‑time commissioning, worldwide

Endress+Hauser’s qualified service engineers ensure your measurement devices are commissioned right the first time, delivering application‑aligned accuracy, regulatory compliance, and operational confidence from startup onwards, anywhere in the world.

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With Endress+Hauser Smart Support, you benefit from faster issue resolution, higher uptime, reliable global expertise across the entire product lifecycle – and lasting peace of mind.

Committed to long‑term, sustainable performance

With deep field expertise, harmonized processes, and continuous monitoring, we accompany you with comprehensive service offerings – from initial start‑up through instrumentation maintenance to process optimization – as a true lifetime partner delivering improved outcomes.

For additional information, please contact your local Endress+Hauser representative.

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Technology

Raman spectroscopy - advanced optical analysis technology

Boost plant safety, ensure product quality, and optimize operations. Raman spectroscopy measures the composition and molecular structure of your samples from lab-to-process in real time.

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Product information

Product picture Raman Rxn-45 probe side view aiming right
Raman Rxn-45 probe
Specifications
Measuring / Application task Liquids

Measuring principle

Raman spectroscopy

Laser wavelength


785 nm, 1000 nm

Spectral coverage

Probe spectral coverage is limited by the coverage of the analyzer being used.

Ambient temperature


-30 to 70 °C / -22 to 158 °F

Maximum laser power into probehead (mW)

< 499

Sample interface

Temperature:
-30 to 150 °C / -22 to 302 °F
Temperature ramp:
≤ 30 °C/min
≤ 54 °F/min

Pressure

Max pressure:
13.8 barg / 200 psig

Wetted materials

Body: 316L stainless steel
Window: Proprietary material, optimized for bioprocesses
Process connection: PG13.5 for industry standard sensor housings, welded port connectors available
Surface finish: Ra 15 with electropolish
Adhesive: USP Class VI and ISO993 compatible

Fiber optic cable

Cable sold separately

Length

120 mm / 4.73 inch

Diameter

12 mm / 0.48 inch

Sterilization method

CIP/SIP
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Description

The Raman Rxn-45 probe capitalizes on the power of Raman in bioprocess manufacturing by measuring multiple, specific components in real-time for continuous, around-the-clock process feedback. It also meets the daunting sampling requirements of compliance, sterilization, port compatibility, and convenience. The Raman Rxn-45 probe was designed for installation in development and cGMP stainless-steel reactors and is successfully used to provide an analytical “eye” into large-scale bioprocesses.

Field of application
  • Cell culture: glucose, lactate, amino acids, cell density, titer, and more
  • Fermentation: glucose, glycerol, acetate, methanol, ethanol, biomass, and more
Benefits
  • Measures multiple components in real-time for automated 24/7 process feedback
  • Provides long-term measurement stability
  • Offers a suitable surface finish for cGMP manufacturing
  • Provides compatibility with industry standard bioreactor side ports and sensor housings
  • Offers the flexibility of being installed in development and production reactors
  • Reduces sterilization and cleaning burdens with CIP/SIP standard compatibility
Downloads
Most downloaded
Technical Information (TI)
Rxn-45 Raman spectroscopic probe Technical Information System design and specifications for the Raman Rxn-45 probe
English version - 10/2025
Download
Short Instruction (KA)
Rxn-45 Raman spectroscopic probe Brief Operating Instructions Quick start guide for the Raman Rxn-45 probe
English version - 12/2024
Download
Operating Instruction (BA)
Rxn-45 Raman spectroscopic probe Operating Instructions Commissioning, operation, and maintenance details
for the Raman Rxn-45 probe
English version - 10/2025
Download
The CAD Drawings will be available after the configuration.
More options
Download page as PDF Search downloads by serial number
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Download page as PDF Search downloads by serial number
All downloads
54 Downloads
Technical Information (TI)
Most downloaded
Rxn-45 Raman spectroscopic probe Technical Information System design and specifications for the Raman Rxn-45 probe
English version - 10/2025
Download
Operating Instruction (BA)
Rxn-45 Raman spectroscopic probe Operating Instructions Commissioning, operation, and maintenance details
for the Raman Rxn-45 probe
English version - 10/2025
Download
Short Instruction (KA)
Most downloaded
Rxn-45 Raman spectroscopic probe Brief Operating Instructions Quick start guide for the Raman Rxn-45 probe
English version - 12/2024
Download
PU (Publication)
Top must-read Biopharma 4.0 articles - Stay informed about the latest research embracing Biopharma 4.0 principles A list of published technical articles related to Biopharma 4.0
topics with recommendations from Life Science industry experts
at Endress+Hauser.
English version - 06/2025
Download
PU (Publication)
Biopharma 4.0 model graphic Graphic illustrating the core elements of Biopharma 4.0 including
product lifecycle stages, role of PAT/QbD, and 12 key advanced
technologies for scientists and process engineers in the Life
Sciences, applicable to Raman spectroscopy systems (Raman
Rxn2, Raman Rxn4, Rxn-10, Rxn-45, Rxn-46, bio multi optic and
sleeve, flow cell and flow bench, Raman optic system for single
use, and Raman calibration & verification kits).
English version - 05/2025
Download
PU (Publication)
Endress+Hauser - ライフサイエンス技術のワンストップパートナー Endress+Hauserが、ライフサイエンス分野の専門知識と、ラマン分
光システム（Raman Rxn2、Raman Rxn4、Rxn-10、Rxn-45、Rxn-46、
バイオマルチオプティックおよびスリーブ、フローフィル、フロー
ベンチ、シングルユース用Ramanオプティックシステム）や水質分
析センサ技術（Liquiline CM44P、CM442、OUSAF44、OUSBT66、
Memosens CPS61E、CLS82E、COS81E、CLS82E）などの信頼性の高い
インラインおよびリアルタイム測定技術によって、世界トップクラ
スのバイオ医薬品メーカーから信頼されている理由を強調したグラ
フィック。
Japanese version - 10/2024
Download
PU (Publication)
Bioprocessing infrastructure readiness for online analytical instrumentation integration - Is your upstream operation ready for seamless deployment of an online Raman spectroscopy system? This self-assessment questionnaire helps pharmaceutical and API
manufacturers evaluate their readiness for implementing online
Raman spectroscopy. A simple scoring system identifies potential
infrastructure, integration, and process monitoring challenges, helping
teams assess deployment complexity and prepare for successful
real-time analytical monitoring.
English version - 08/2026
Download
PU (Publication)
Analytical costs, scale-up delays, and optimization potential in upstream bioprocessing - Is your upstream process costing more than you think? This self-assessment questionnaire helps bioprocessing teams evaluate
analytical costs and delays associated with scaling up from laboratory
development to production. A scoring system helps identify optimization
opportunities and assess the value of real-time monitoring using online
Raman spectroscopy.
English version - 08/2026
Download
PU (Publication)
Biopharma 4.0 model graphic (full version) Expanded version of a graphic illustrating the core elements of
Biopharma 4.0 including product lifecycle stages, role of
PAT/QbD, and 12 key advanced technologies for scientists and
process engineers in the Life Sciences, applicable to Raman
spectroscopy systems (Raman Rxn2, Raman Rxn4, Rxn-10,
Rxn-45, Rxn-46, bio multi optic and sleeve, flow cell and flow
bench, Raman optic system for single use, and Raman calibration
& verification kits).
English version - 05/2025
Download
PU (Publication)
Raman-Anwendungsleitfaden für die Life-Sciences-Industrie Ein Leitfaden zu unseren Anwendungshinweisen zur
Raman-Spektroskopie für die Life-Science-Industrie
(Raman Rxn2-Analysator, Raman Rxn4-Analysator,
Rxn-10-Sonde, Rxn-20-Sonde, Rxn-45-Sonde,
Rxn-46-Sonde und Zubehör für Sondenoptiken
(blO-Optic, Raman- Single Use-Optiksystem
/ SUB, Immersionsoptik, berührungslose Optik)
German version - 09/2025
Download
PU (Publication)
ライフサイエンスにおけるラボからプロセスまでの監視と制御 バイオプロセスの物理的・化学的特性の信頼性の高い測定 この製品リストは、ライフサイエンス業界におけるバイオプロセス
用途向けに、光学分析および液体分析の両方から提供される分析機
器をまとめたものです。含まれる製品には、Raman Rxn2アナライザ
、Raman Rxn4アナライザ、Rxn-10プローブ、バイオマルチオプティ
ックおよびバイオスリーブ、ラマンフローアセンブリ、Rxn-45プロ
ーブ、Rxn-46プローブ、シングルユース向けラマンオプティックシ
ステム、Memosens CPS61E、Memosens COS81E、OUSBT66、Memosens
CPS77E、Memosens CLS82E、OUSAF44、Memosens CPS11E、Memosens
CLS16E、TOCアナライザーCA79、Liquiline変換器プラットフォーム
、およびMemobaseソフトウェアが含まれています。
Japanese version - 08/2025
Download
PU (Publication)
Prioritize scalability for an efficient biopharmaceutical product development lifecycle This technical paper studies the importance of scalability as a
competitive advantage in bioprocessing in the Life Science industry,
and Endress+Hauser's scalable Raman systems (Raman Rxn2,
Raman Rxn4, Rxn-10, Rxn-45, Rxn-46, bio multi optic and sleeve,
flow cell and flow bench, Raman optic system for single use) and
liquid analysis sensor technology and Liquid Analysis portfolio
(Liquiline CM44P, CM442 and OUSAF44, OUSBT66 and
Memosens CPS61E, CLS82E, COS81E, CLS82E).
Czech version - 09/2024
Download
PU (Publication)
Advanced process and product control in fermentations - Raman spectroscopy for composition analysis in a lab or process An overview of Raman spectroscopy analyzer systems (including the
Raman Rxn2 analyzer, Raman Rxn4 analyzer, Rxn-10 probe, and Rxn-45
probe), powered by Kaiser Raman technology, for fermentation
compositional analysis in a lab or process applicable to biotechnology
in the food & beverage industry.
English version - 03/2022
Download
PU (Publication)
Raman application guide for the life science industry - Trusted composition analysis for the life sciences A guide to our Raman spectroscopy application notes for the
Life Science industry (featuring the Raman Rxn2 analyzer,
Raman Rxn4 analyzer, Rxn-10 probe, Rxn-20 probe, Rxn-45 probe,
Rxn-46 probe, and probe accessory optics (bIO-Optic, Raman single
use optic system / SUB, immersion optic, non-contact optic).
English version - 04/2022
Download
PU (Publication)
効率的なバイオ医薬品の製品開発ライフサイクルのために拡張性を優先 この技術文書では、ライフサイエンス産業におけるバイオプロセス
の競争優位性としての拡張性の重要性と、Endress+Hauserの拡張性
のあるラマンシステム（Raman Rxn2、Raman Rxn4、Rxn-10、Rxn-45
、Rxn-46、バイオマルチオプティックおよびスリーブ、フローフィ
ル、フローベンチ、シングルユース用Ramanオプティックシステム）
、水質分析センサ技術、および水質分析製品ラインナップ
（LiquilineCM44P、CM442、OUSAF44、OUSBT66、Memosens CPS61E、
CLS82E、COS81E、CLS82E）について考察しています。
Japanese version - 10/2024
Download
PU (Publication)
Raman spectroscopy in GMP environments This guide explains Raman spectroscopy implementation in
GMP-regulated pharmaceutical and biopharmaceutical
manufacturing, covering qualification, validation, data
integrity, supplier and user responsibilities, and
risk-based compliance approaches for process analytical
technology applications.
English version - 08/2026
Download
PU (Publication)
Real-time analytical control of your API synthesis process - Is your API crystallization process truly under control between lab analyses? This self-assessment questionnaire helps API synthesis teams in the
Life Sciences industry identify analytical blind spots and assess the
value of real-time inline Raman spectroscopy for monitoring API
crystallization processes.
English version - 08/2026
Download
PU (Publication)
Analytical blind spots and contamination risks in upstream bioprocessing - Are your cell cultures truly under control between measurements? This self-assessment questionnaire helps cell culture and upstream
bioprocessing teams identify analytical blind spots, contamination
risks from manual sampling, and opportunities to improve process
control through real-time monitoring. A simple scoring system
highlights where online Raman spectroscopy may help improve data
quality, reduce risk, and support faster process decisions.
English version - 08/2026
Download
PU (Publication)
ライフサイエンス産業向けのラマンアプリケーションガイド -ライフサイエンスのための信頼できる組成分析 ライフサイエンス産業向けラマン分光法アプリケーションノート（
ラマンRxn2アナライザー、ラマンRxn4アナライザー、Rxn-10プロー
ブ、Rxn-20プローブ、Rxn-45プローブ、Rxn-46プローブ、プローブ
オプティックアクセサリ（bIOオプティック、シングルユース向け
ラマンオプティックシステム/SUB、浸漬オプティック、非接触オプ
ティック）。
Japanese version - 08/2024
Download
PU (Publication)
Prioritize scalability for an efficient biopharmaceutical product development lifecycle This technical paper studies the importance of scalability as a
competitive advantage in bioprocessing in the Life Science industry,
and Endress+Hauser's scalable Raman systems (Raman Rxn2,
Raman Rxn4, Rxn-10, Rxn-45, Rxn-46, bio multi optic and sleeve,
flow cell and flow bench, Raman optic system for single use) and
liquid analysis sensor technology and Liquid Analysis portfolio
(Liquiline CM44P, CM442 and OUSAF44, OUSBT66 and
Memosens CPS61E, CLS82E, COS81E, CLS82E).
English version - 06/2024
Download
PU (Publication)
The Biopharma 4.0 glossary - Test your Biopharma 4.0 IQ A list of definitions and sources for frequently used terms and
abbreviations in the biopharmaceutical industry related to
Biopharma 4.0.
English version - 06/2025
Download
PU (Publication)
Process infrastructure readiness assessment for in-line Raman spectroscopy - Is your facility ready to integrate an in-line analytical monitoring system without major modifications? This self-assessment questionnaire helps pharmaceutical and API
manufacturing teams evaluate their readiness for deploying online
Raman spectroscopy and other real-time analytical monitoring
technologies. A simple scoring system highlights the maturity of
existing process infrastructure and helps estimate the effort
required to successfully implement real-time process analytics.
English version - 08/2026
Download
PU (Publication)
Asset utilization and cost of non-conformance in API manufacturing - Are hidden analytical costs and process inefficiencies impacting your API production? This self-assessment questionnaire helps API and pharmaceutical
manufacturing teams identify the financial impact of analytical delays,
asset idle time, and batch nonconformities during multi-step synthesis
processes. A simple scoring system helps quantify optimization
opportunities and assess the potential value of real-time process
monitoring using online Raman spectroscopy to improve throughput,
reduce risk, and maximize asset utilization.
English version - 08/2026
Download
PU (Publication)
Lab-to-process monitoring & control in Life Sciences - Reliable measurement of bioprocess physical and chemical properties A combined product list of analysis offerings from both Optical Analysis
and LIquid Analysis for bioprocessing applications in the life science
industry (including Raman Rxn2 analyzer, Raman Rxn4 analyzer,
Rxn-10 probe, bio multi optic and bio sleeve, Raman flow assembly,
Rxn-45 probe, Rxn-46 probe, Raman optic system for single use,
Memosens CPS61E, Memosens COS81E, OUSBT66, Memosens CPS61E,
Memosens CPS77E, Memosens CLS82E, OUSAF44, Memosens CPS11E,
Memosens CLS16E, TOC Analyzer CA79, Liquiline transmitter platform, and
Memobase software).
English version - 04/2024
Download

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Brochure image Raman spectroscopic probes and accessories by Endress+Hauser
Company facts

Raman spectroscopic probes

Raman spectroscopic probes and accessories - Robust optical measurement of chemical composition

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Product picture Raman Rxn-45 probe side view aiming right
Raman Rxn-45 probe

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Spare parts and accessories

further parts
further parts

Optic caps pack

further parts
further parts
Order code 70197449
further parts
further parts

Raman Rxn-45 KR45

further parts
further parts
Order code KR45-
further parts
further parts

Raman fiber-optic cable

further parts
further parts
Order code KFOC1B-

KLBIO1/Rxn-45 verification chamber SC

Order code 70187796
Spare parts and accessories
20 results
further parts
further parts

Optic caps pack

Optic caps pack

further parts
further parts
Order code 70197449
further parts
further parts

Raman Rxn-45 KR45

Raman Rxn-45 KR45

further parts
further parts
Order code KR45-
further parts
further parts

Raman fiber-optic cable

Raman fiber-optic cable

further parts
further parts
Order code KFOC1B-

KLBIO1/Rxn-45 verification chamber SC

KLBIO1/Rxn-45 verification chamber SC

Order code 70187796
No results found Try adjusting your search terms to see more results.

Selection of compatible products

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Fast, simple, and accurate wavelength and intensity calibration for Raman analyzers

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