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Raman flow cell

Reduce downstream bioprocessing costs and ensure safer patient outcomes

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Raman flow cell

Reduce downstream bioprocessing costs and ensure safer patient outcomes

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Benefits

  • The Raman flow bench houses a Raman flow cell and easily connects to an Rxn-10 probe paired with a Raman Rxn embedded analyzer, and ensures transferability when used with the Raman flow assembly calibration and verification kit
  • Provides continuous, real-time measurements with high sensitivity for development-scale flow rates  
  • Achieves lower limits of detection through enhancement of the Raman signal  
  • Brings Raman-based process insights and control to downstream bioprocessing unit operations 

Integrated technologies

Raman spectroscopy - advanced optical analysis technology
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Raman flow cell

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Manufacturer's warranty

Engineered for confidence

Our instruments are designed for long‑lasting performance, precise measurement, and dependable operation in demanding industrial environments. Each product includes a standard manufacturer’s warranty that reflects our commitment to quality and to the trust you place in our solutions.

Should a warranty case occur, the device will be assessed and the applicable remedy will be provided in line with the warranty terms – helping ensure a reliable and efficient resolution and supporting continued operation of your measurement point.

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The manufacturer's warranty and extended warranty are subject to specific conditions. For full details, please refer to the locally applicable General Terms and Conditions (GTC), which can be found on the respective country page of our website.

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Technology

Raman spectroscopy - advanced optical analysis technology

Boost plant safety, ensure product quality, and optimize operations. Raman spectroscopy measures the composition and molecular structure of your samples from lab-to-process in real time.

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Product information

Image of a Raman micro flow cell for downstream bioprocessing
Raman flow cell
Specifications
Measuring / Application task Liquid: Flow cell
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Description

The Raman flow cell meets the speed demands of downstream by optimizing Raman collection for low-turbidity, low volume samples. Ideally suited for development-scale flow rates, the Raman flow cell allows real-time monitoring, rapid process optimization, and process control for chromatography and other downstream unit operations.

Field of application
  • Downstream: aggregation, protein crystallization, formula stability, product CQA, protein concentration, buffer excipients
Benefits
  • The Raman flow bench houses a Raman flow cell and easily connects to an Rxn-10 probe paired with a Raman Rxn embedded analyzer, and ensures transferability when used with the Raman flow assembly calibration and verification kit
  • Provides continuous, real-time measurements with high sensitivity for development-scale flow rates  
  • Achieves lower limits of detection through enhancement of the Raman signal  
  • Brings Raman-based process insights and control to downstream bioprocessing unit operations 
Downloads
Most downloaded
Technical Information (TI)
Raman flow assembly Technical Information System design and specifications for the Raman flow assembly
(KRFB, KRFC)
English version - 06/2023
Download
Technical Information (TI)
Raman flow assembly calibration and verification kit Technical Information System design and specifications for the Raman flow assembly calibration
and verification kit
English version - 06/2023
Download
Operating Instruction (BA)
Raman flow assembly Operating Instructions Commissioning, operation, and maintenance details for the
Raman flow assembly (KRFB, KRFC)
English version - 06/2023
Download
The CAD Drawings will be available after the configuration.
All downloads
45 Downloads
Technical Information (TI)
Raman flow assembly Technical Information System design and specifications for the Raman flow assembly
(KRFB, KRFC)
English version - 06/2023
Download
Technical Information (TI)
Raman flow assembly calibration and verification kit Technical Information System design and specifications for the Raman flow assembly calibration
and verification kit
English version - 06/2023
Download
Operating Instruction (BA)
Raman flow assembly Operating Instructions Commissioning, operation, and maintenance details for the
Raman flow assembly (KRFB, KRFC)
English version - 06/2023
Download
Operating Instruction (BA)
Raman flow assembly calibration and verification kit Operating Instructions Commissioning, operation, and maintenance details for the
Raman flow assembly calibration and verification kit
English version - 06/2023
Download
PU (Publication)
Top must-read Biopharma 4.0 articles - Stay informed about the latest research embracing Biopharma 4.0 principles A list of published technical articles related to Biopharma 4.0
topics with recommendations from Life Science industry experts
at Endress+Hauser.
English version - 06/2025
Download
PU (Publication)
Endress+Hauser - ライフサイエンス技術のワンストップパートナー Endress+Hauserが、ライフサイエンス分野の専門知識と、ラマン分
光システム(Raman Rxn2、Raman Rxn4、Rxn-10、Rxn-45、Rxn-46、
バイオマルチオプティックおよびスリーブ、フローフィル、フロー
ベンチ、シングルユース用Ramanオプティックシステム)や水質分
析センサ技術(Liquiline CM44P、CM442、OUSAF44、OUSBT66、
Memosens CPS61E、CLS82E、COS81E、CLS82E)などの信頼性の高い
インラインおよびリアルタイム測定技術によって、世界トップクラ
スのバイオ医薬品メーカーから信頼されている理由を強調したグラ
フィック。
Japanese version - 10/2024
Download
PU (Publication)
Biopharma 4.0 model graphic Graphic illustrating the core elements of Biopharma 4.0 including
product lifecycle stages, role of PAT/QbD, and 12 key advanced
technologies for scientists and process engineers in the Life
Sciences, applicable to Raman spectroscopy systems (Raman
Rxn2, Raman Rxn4, Rxn-10, Rxn-45, Rxn-46, bio multi optic and
sleeve, flow cell and flow bench, Raman optic system for single
use, and Raman calibration & verification kits).
English version - 05/2025
Download
PU (Publication)
Raman flow assembly - Precise composition measurement of high-speed, low-volume samples in downstream bioprocessing An overview of the Raman flow assembly (flow bench and flow cell)
used with the Rxn-10 probe in conjunction with a Raman Rxn2
analyzer and a Raman flow assembly calibration and verification kit
for downstream bioprocessing (powered by Kaiser Raman technology).
English version - 05/2023
Download
PU (Publication)
Bioprocessing infrastructure readiness for online analytical instrumentation integration - Is your upstream operation ready for seamless deployment of an online Raman spectroscopy system? This self-assessment questionnaire helps pharmaceutical and API
manufacturers evaluate their readiness for implementing online
Raman spectroscopy. A simple scoring system identifies potential
infrastructure, integration, and process monitoring challenges, helping
teams assess deployment complexity and prepare for successful
real-time analytical monitoring.
English version - 08/2026
Download
PU (Publication)
Analytical costs, scale-up delays, and optimization potential in upstream bioprocessing - Is your upstream process costing more than you think? This self-assessment questionnaire helps bioprocessing teams evaluate
analytical costs and delays associated with scaling up from laboratory
development to production. A scoring system helps identify optimization
opportunities and assess the value of real-time monitoring using online
Raman spectroscopy.
English version - 08/2026
Download
PU (Publication)
効率的なバイオ医薬品の製品開発ライフサイクルのために拡張性を優先 この技術文書では、ライフサイエンス産業におけるバイオプロセス
の競争優位性としての拡張性の重要性と、Endress+Hauserの拡張性
のあるラマンシステム(Raman Rxn2、Raman Rxn4、Rxn-10、Rxn-45
、Rxn-46、バイオマルチオプティックおよびスリーブ、フローフィ
ル、フローベンチ、シングルユース用Ramanオプティックシステム)
、水質分析センサ技術、および水質分析製品ラインナップ
(LiquilineCM44P、CM442、OUSAF44、OUSBT66、Memosens CPS61E、
CLS82E、COS81E、CLS82E)について考察しています。
Japanese version - 10/2024
Download
PU (Publication)
ライフサイエンスにおけるラボからプロセスまでの監視と制御 バイオプロセスの物理的・化学的特性の信頼性の高い測定 この製品リストは、ライフサイエンス業界におけるバイオプロセス
用途向けに、光学分析および液体分析の両方から提供される分析機
器をまとめたものです。含まれる製品には、Raman Rxn2アナライザ
、Raman Rxn4アナライザ、Rxn-10プローブ、バイオマルチオプティ
ックおよびバイオスリーブ、ラマンフローアセンブリ、Rxn-45プロ
ーブ、Rxn-46プローブ、シングルユース向けラマンオプティックシ
ステム、Memosens CPS61E、Memosens COS81E、OUSBT66、Memosens
CPS77E、Memosens CLS82E、OUSAF44、Memosens CPS11E、Memosens
CLS16E、TOCアナライザーCA79、Liquiline変換器プラットフォーム
、およびMemobaseソフトウェアが含まれています。
Japanese version - 08/2025
Download
PU (Publication)
Biopharma 4.0 model graphic (full version) Expanded version of a graphic illustrating the core elements of
Biopharma 4.0 including product lifecycle stages, role of
PAT/QbD, and 12 key advanced technologies for scientists and
process engineers in the Life Sciences, applicable to Raman
spectroscopy systems (Raman Rxn2, Raman Rxn4, Rxn-10,
Rxn-45, Rxn-46, bio multi optic and sleeve, flow cell and flow
bench, Raman optic system for single use, and Raman calibration
& verification kits).
English version - 05/2025
Download
PU (Publication)
Prioritize scalability for an efficient biopharmaceutical product development lifecycle This technical paper studies the importance of scalability as a
competitive advantage in bioprocessing in the Life Science industry,
and Endress+Hauser's scalable Raman systems (Raman Rxn2,
Raman Rxn4, Rxn-10, Rxn-45, Rxn-46, bio multi optic and sleeve,
flow cell and flow bench, Raman optic system for single use) and
liquid analysis sensor technology and Liquid Analysis portfolio
(Liquiline CM44P, CM442 and OUSAF44, OUSBT66 and
Memosens CPS61E, CLS82E, COS81E, CLS82E).
Czech version - 09/2024
Download
PU (Publication)
Real-time analytical control of your API synthesis process - Is your API crystallization process truly under control between lab analyses? This self-assessment questionnaire helps API synthesis teams in the
Life Sciences industry identify analytical blind spots and assess the
value of real-time inline Raman spectroscopy for monitoring API
crystallization processes.
English version - 08/2026
Download
PU (Publication)
Analytical blind spots and contamination risks in upstream bioprocessing - Are your cell cultures truly under control between measurements? This self-assessment questionnaire helps cell culture and upstream
bioprocessing teams identify analytical blind spots, contamination
risks from manual sampling, and opportunities to improve process
control through real-time monitoring. A simple scoring system
highlights where online Raman spectroscopy may help improve data
quality, reduce risk, and support faster process decisions.
English version - 08/2026
Download
PU (Publication)
Prioritize scalability for an efficient biopharmaceutical product development lifecycle This technical paper studies the importance of scalability as a
competitive advantage in bioprocessing in the Life Science industry,
and Endress+Hauser's scalable Raman systems (Raman Rxn2,
Raman Rxn4, Rxn-10, Rxn-45, Rxn-46, bio multi optic and sleeve,
flow cell and flow bench, Raman optic system for single use) and
liquid analysis sensor technology and Liquid Analysis portfolio
(Liquiline CM44P, CM442 and OUSAF44, OUSBT66 and
Memosens CPS61E, CLS82E, COS81E, CLS82E).
English version - 06/2024
Download
PU (Publication)
The Biopharma 4.0 glossary - Test your Biopharma 4.0 IQ A list of definitions and sources for frequently used terms and
abbreviations in the biopharmaceutical industry related to
Biopharma 4.0.
English version - 06/2025
Download
PU (Publication)
ラマン校正および検証キット ラボからプロセスへの拡張性を実現するラマン分光計システムの校 正と検証のために必要なものすべて バイオマルチオプティック/シングルユースオプティックおよびラ
マンフローアセンブリ(フローベンチとフローセルを含む)用のラ
マン校正および検証キットの概要です。これらのキットは、Kaiser
ラマンテクノロジーを搭載したRxn-10プローブおよびRaman Rxn2 /
Rxn4アナライザーと併用し、バイオプロセスの上流および下流工
程で使用されます。
Japanese version - 08/2025
Download
PU (Publication)
Raman Flow Assembly -Genaue Messung der Zusammensetzung von kleinvolumigen Proben bei hoher Geschwindigkeit in Downstream-Bioprozessen Übersicht über Raman-Flow Assembly (Flow Bench und Flow Cell),
die mit der Rxn-10-Sonde in Verbindung mit einem Raman Rxn-2-Analysator
und einem Kalibrierungs- und Verifizierungskit für die
Raman-Flow Assembly für die Downstream-Bioprozessierung
(basierend auf der Kaiser Raman-Technologie) verwendet wird.
German version - 08/2025
Download
PU (Publication)
Asset utilization and cost of non-conformance in API manufacturing - Are hidden analytical costs and process inefficiencies impacting your API production? This self-assessment questionnaire helps API and pharmaceutical
manufacturing teams identify the financial impact of analytical delays,
asset idle time, and batch nonconformities during multi-step synthesis
processes. A simple scoring system helps quantify optimization
opportunities and assess the potential value of real-time process
monitoring using online Raman spectroscopy to improve throughput,
reduce risk, and maximize asset utilization.
English version - 08/2026
Download
PU (Publication)
Process infrastructure readiness assessment for in-line Raman spectroscopy - Is your facility ready to integrate an in-line analytical monitoring system without major modifications? This self-assessment questionnaire helps pharmaceutical and API
manufacturing teams evaluate their readiness for deploying online
Raman spectroscopy and other real-time analytical monitoring
technologies. A simple scoring system highlights the maturity of
existing process infrastructure and helps estimate the effort
required to successfully implement real-time process analytics.
English version - 08/2026
Download
PU (Publication)
Endress+Hauser - your one-source Life Sciences technology partner Graphic highlighting why Endress+Hauser is trusted by the
world's top biopharmaceutical manufacturers for its Life
Sciences expertise and reliable inline, real-time measurement
technologies like Raman spectroscopy systems (Raman Rxn2,
Raman Rxn4, Rxn-10, Rxn-45, Rxn-46, bio multi optic and sleeve,
flow cell and flow bench, Raman optic system for single use) and
liquid analysis sensor technology (Liquiline CM44P, CM442 and
OUSAF44, OUSBT66 and Memosens CPS61E, CLS82E, COS81E,
CLS82E).
English version - 06/2024
Download
PU (Publication)
Endress+Hauser - your one-source Life Sciences technology partner Graphic highlighting why Endress+Hauser is trusted by the
world's top biopharmaceutical manufacturers for its Life
Sciences expertise and reliable inline, real-time measurement
technologies like Raman spectroscopy systems (Raman Rxn2,
Raman Rxn4, Rxn-10, Rxn-45, Rxn-46, bio multi optic and sleeve,
flow cell and flow bench, Raman optic system for single use) and
liquid analysis sensor technology (Liquiline CM44P, CM442 and
OUSAF44, OUSBT66 and Memosens CPS61E, CLS82E, COS81E,
CLS82E).
Czech version - 09/2024
Download

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