Virus filtration (tangential flow filtration)

Map view Table view

Measuring point	Product	Alternatives
Tank level monitoring	Micropilot FMR43 – radar sensor for hygienic processes	Micropilot FMR63B – 80 GHz radar sensor
Retentate flow	Proline Promass P 100 Coriolis flowmeter	Proline Promag H 100 electromagnetic flowmeter	Proline Promag H 500 electromagnetic flowmeter
Temperature	iTHERM ModuLine TM411 Hygienic modular thermometer	iTHERM ModuLine TM412 Hygienic modular thermometer	TMR35 Compact thermometer
Retentate pressure	Cerabar PMP43 – hygienic pressure transmitter	Absolute and gauge pressure Cerabar PMC51	Absolute and gauge pressure Cerabar PMP23	Absolute and gauge pressure Ceraphant PTP33B
Permeate pressure	Cerabar PMP43 – hygienic pressure transmitter	Absolute and gauge pressure Cerabar PMC51	Absolute and gauge pressure Cerabar PMP23	Absolute and gauge pressure Ceraphant PTP33B
Feed pressure	Cerabar PMP43 – hygienic pressure transmitter	Absolute and gauge pressure Cerabar PMC51	Absolute and gauge pressure Cerabar PMP23	Absolute and gauge pressure Ceraphant PTP33B
Temperature	iTHERM ModuLine TM411 Hygienic modular thermometer	iTHERM ModuLine TM412 Hygienic modular thermometer	TMR35 Compact thermometer
Permeate UV	UV absorption sensor OUSAF44	UV absorption sensor OUSAF44
Permeate flow	Proline Promass P 100 Coriolis flowmeter	Proline Promag H 100 electromagnetic flowmeter	Proline Promag H 500 electromagnetic flowmeter
System pH	Digital pH sensor Memosens CPS61E	Digital non-glass pH sensor Memosens CPS77E
System conductivity	Digital 4-electrode conductivity sensor Memosens CLS82E	Digital conductivity sensor Indumax CLS54D	Conductivity compact device Smartec CLD134
Retentate pH	Digital pH sensor Memosens CPS61E	Digital non-glass pH sensor Memosens CPS77E
Retentate conductivity	Digital 4-electrode conductivity sensor Memosens CLS82E	Digital conductivity sensor Indumax CLS54D	Conductivity compact device Smartec CLD134
Retentate UV	UV absorption sensor OUSAF44

Level measurement in: Tank level monitoring

Endress+Hauser offers a suite of analytical instruments ideal for this stage.

Micropilot FMR43 – radar sensor for hygienic processes

High performance sensor, especially compact and the perfect fit for fast changing level applications

Alternatives:

Micropilot FMR63B – 80 GHz radar sensor

More simplicity with the specialist for hygienic applications

General Requirements:

Cleanability, no dead legs, front flush mounting
No interaction with agitator operation
Design according to ASME BPE standard

Technical requirements:

Measuring task: Continuous / Liquids
Process pressure: 0 to 16 bar (0 to 232 psi)
Max. process temperature: 40°C (104°F)
CIP/SIP: 130°C (266°F)
Density: 0.8 to 1.25 g/cm³

Flow measurement in: Retentate flow

Endress+Hauser offers a suite of analytical instruments ideal for this stage.

Picture of Coriolis flowmeter Proline Promass P 100 / 8P1B for the life sciences industry

Proline Promass P 100 Coriolis flowmeter

The specialist for life sciences with an ultra-compact transmitter

Alternatives:

Picture of flowmeter Proline Promag H 100 / 5H1B (DN ≥ 40 / 1 1/2") for hygienic applications

Proline Promag H 100 electromagnetic flowmeter

The specialist for hygienic applications with an ultra-compact transmitter

Electromagnetic flowmeter Proline Promag H 500 for the food & beverages and life sciences industries

Proline Promag H 500 electromagnetic flowmeter

Specialist for hygienic applications, as remote version with up to 4 I/Os

General Requirements:

Cleanability (CIP/SIP), no dead legs
Fully self-drainable in horizontal installations
Design according to ASME BPE standard
High reproducibility over a large flow range
Small quantities

Technical requirements:

Measuring task: Liquids
Process pressure: 0 to 16 bar (0 to 232 psi)
Max. process temperature: 40 °C (104 °F)
CIP/SIP: 130°C (266°F)
Density: 0.8 to 1.25 g/cm³

Temperature measurement in: Temperature

Endress+Hauser offers a suite of analytical instruments ideal for this stage.

Sanitary digital thermometer iTHERM TM411

iTHERM ModuLine TM411 Hygienic modular thermometer

Metric RTD thermometer with or without thermowell for hygienic applications

Alternatives:

Hygienic thermometer iTHERM TM412 - Imperial version US Style

iTHERM ModuLine TM412 Hygienic modular thermometer

Imperial RTD thermometer with or without thermowell for hygienic applications

Product picture hygienic compact thermometer TMR35

TMR35 Compact thermometer

Metric RTD 4-20 mA compact thermometer for hygienic applications

General Requirements:

Cleanability, no dead legs, front flush mounting
Installation in thermowell
Easy calibration
Long-term stability
Linearity over the measurement range
Design according to ASME BPE standard

Technical requirements:

Measuring task: Thermometer
Process pressure: 0 to 16 bar (0 to 232 psi)
Max. process temperature: 40°C (104°F)
CIP/SIP: 130°C (266°F)
Density: 0.8 to 1.25 g/cm³

Pressure measurement in: Retentate pressure

Endress+Hauser offers a suite of analytical instruments ideal for this stage.

Cerabar PMP43 – hygienic pressure transmitter

Particularly compact, highly reliable and the perfect fit for demanding hygienic applications

Alternatives:

Cerabar PMC51 - Absolute and gauge pressure

Absolute and gauge pressure Cerabar PMC51

Digital pressure transmitter with oil-free ceramic sensor for measurement in gases or liquids

Absolute and gauge pressure Cerabar PMP23

Cost-effective pressure transducer with fully welded design for the food & beverage industry

Ceraphant PTP33B - Absolute and gauge pressure

Absolute and gauge pressure Ceraphant PTP33B

Cost-effective pressure switch with fully welded metal sensor for use in hygienic applications

General Requirements:

Front flush mounting for drainability
Fast temperature shock response
High linearity
Design according to ASME BPE standard

Technical requirements:

Measuring task: Pressure
Process pressure: 0 to 16 bar (0 to 232 psi)
Max. process temperature: 40°C (104°F)
CIP/SIP: 130°C (266°F)
Density: 0.8 to 1.25 g/cm³

Pressure measurement in: Permeate pressure

Endress+Hauser offers a suite of analytical instruments ideal for this stage.

Cerabar PMP43 – hygienic pressure transmitter

Particularly compact, highly reliable and the perfect fit for demanding hygienic applications

Alternatives:

Absolute and gauge pressure Cerabar PMC51

Digital pressure transmitter with oil-free ceramic sensor for measurement in gases or liquids

Absolute and gauge pressure Cerabar PMP23

Cost-effective pressure transducer with fully welded design for the food & beverage industry

Absolute and gauge pressure Ceraphant PTP33B

Cost-effective pressure switch with fully welded metal sensor for use in hygienic applications

General Requirements:

Front flush mounting for drainability
Fast temperature shock response
High linearity
Design according to ASME BPE standard

Technical requirements:

Measuring task: Pressure
Process pressure: 0 to 16 bar (0 to 232 psi)
Max. process temperature: 40°C (104°F)
CIP/SIP: 130°C (266°F)
Density: 0.8 to 1.25 g/cm³

Pressure measurement in: Feed pressure

Endress+Hauser offers a suite of analytical instruments ideal for this stage.

Cerabar PMP43 – hygienic pressure transmitter

Particularly compact, highly reliable and the perfect fit for demanding hygienic applications

Alternatives:

Absolute and gauge pressure Cerabar PMC51

Digital pressure transmitter with oil-free ceramic sensor for measurement in gases or liquids

Absolute and gauge pressure Cerabar PMP23

Cost-effective pressure transducer with fully welded design for the food & beverage industry

Absolute and gauge pressure Ceraphant PTP33B

Cost-effective pressure switch with fully welded metal sensor for use in hygienic applications

General Requirements:

Front flush mounting for drainability
Fast temperature shock response
High linearity

Technical requirements:

Measuring task: Pressure
Process pressure: 0 to 16 bar (0 to 232 psi)
Max. process temperature: 40°C (104°F)
CIP/SIP: 130°C (266°F)
Density: 0.8 to 1.25 g/cm³

Temperature measurement in: Temperature

Endress+Hauser offers a suite of analytical instruments ideal for this stage.

iTHERM ModuLine TM411 Hygienic modular thermometer

Metric RTD thermometer with or without thermowell for hygienic applications

Alternatives:

iTHERM ModuLine TM412 Hygienic modular thermometer

Imperial RTD thermometer with or without thermowell for hygienic applications

TMR35 Compact thermometer

Metric RTD 4-20 mA compact thermometer for hygienic applications

General Requirements:

Cleanability, no dead legs, front flush mounting
Installation in thermowell
Easy calibration
Long-term stability
Linearity over the measurement range
Design according to ASME BPE standard

Technical requirements:

Measuring task: Thermometer
Process pressure: 0 to 16 bar (0 to 232 psi)
Max. process temperature: 40°C (104°F)
CIP/SIP: 130°C (266°F)
Density: 0.8 to 1.25 g/cm³

Analysis measurement in: Permeate UV

Endress+Hauser offers a suite of analytical instruments ideal for this stage.

The OUSAF44 UV sensor accurately monitors the concentration of your product in process liquids.

UV absorption sensor OUSAF44

Sensor for inline product quantification

Alternatives:

UV absorption sensor OUSAF44

Sensor for inline product quantification

General Requirements:

Fast response time
Cleanability (CIP/SIP), gap-free design
Fully self-drainable in horizontal installations
Design according to ASME BPE standard
Smallest hold-up volume

Technical requirements:

Measuring task: Concentration
Process pressure: 0 to 16 bar (0 to 232 psi)
Max. process temperature: 40°C (104°F)
CIP/SIP: 130°C (266°F)
Density: 0.8 to 1.25 g/cm³

Flow measurement in: Permeate flow

Endress+Hauser offers a suite of analytical instruments ideal for this stage.

Proline Promass P 100 Coriolis flowmeter

The specialist for life sciences with an ultra-compact transmitter

Alternatives:

Proline Promag H 100 electromagnetic flowmeter

The specialist for hygienic applications with an ultra-compact transmitter

Proline Promag H 500 electromagnetic flowmeter

Specialist for hygienic applications, as remote version with up to 4 I/Os

General Requirements:

Cleanability (CIP/SIP), no dead legs
Fully self-drainable in horizontal installations
Design according to ASME BPE standard
High reproducibility over a large flow range
Small quantities

Technical requirements:

Measuring task: Liquids
Process pressure: 0 to 16 bar (0 to 232 psi)
Max. process temperature: 40 °C (104 °F)
CIP/SIP: 130°C (266°F)
Density: 0.8 to 1.25 g/cm³

Analysis measurement in: System pH

Endress+Hauser offers a suite of analytical instruments ideal for this stage.

Memosens CPS61E - Digital pH sensor for the food industry and bioreactors in the biotech industry

Digital pH sensor Memosens CPS61E

Memosens 2.0 glass sensor for the food & beverage industry and for bioreactors in biotech industry

Alternatives:

Memosens CPS77E - ISFET pH sensor for food & beverage and life sciences industries

Digital non-glass pH sensor Memosens CPS77E

Memosens 2.0 ISFET pH electrode for food & beverage and life sciences industries

General Requirements:

Cleanability (CIP/SIP), no dead legs
High accuracy
Suitable for CIP/SIP and autoclaves
Long-term stability
Easy and accurate calibration
Design according to ASME BPE standard

Technical requirements:

Measuring task: pH
Process pressure: 0 to 16 bar (0 to 232 psi)
Max. process temperature: 40°C (104°F)
CIP/SIP: 130°C (266°F)
Density: 0.8 to 1.25 g/cm³

Analysis measurement in: System conductivity

Endress+Hauser offers a suite of analytical instruments ideal for this stage.

Memosens CLS82E - Hygienic 4-electrode conductivity sensor for life sciences, food & beverage

Digital 4-electrode conductivity sensor Memosens CLS82E

Memosens 2.0 contacting conductivity sensor for hygienic applications in life sciences, food & bev

Alternatives:

Indumax CLS54D is an inductive conductivity probe for the highest hygienic and sterile demands.

Digital conductivity sensor Indumax CLS54D

Memosens toroidal conductivity sensor for hygienic and sterile applications

Smartec CLD134 is a hygienic conductivity system ensuring the highest process safety and quality.

Conductivity compact device Smartec CLD134

Toroidal conductivity measuring system for hygienic and sterile applications

General Requirements:

Cleanability (CIP/SIP), gap-free design
Wide measurement range 1µS/cm to 100 mS/cm
Suitable for CIP/SIP and autoclaves
Design according to ASME BPE standard

Technical requirements:

Measuring task: Conductivity
Process pressure: 0 to 16 bar (0 to 232 psi)
Max. process temperature: 40°C (104°F)
CIP/SIP: 130°C (266°F)
Density: 0.8 to 1.25 g/cm³

Analysis measurement in: Retentate pH

Endress+Hauser offers a suite of analytical instruments ideal for this stage.

Digital pH sensor Memosens CPS61E

Memosens 2.0 glass sensor for the food & beverage industry and for bioreactors in biotech industry

Alternatives:

Digital non-glass pH sensor Memosens CPS77E

Memosens 2.0 ISFET pH electrode for food & beverage and life sciences industries

General Requirements:

High accuracy
Suitable for CIP/SIP
Long-term stability
Easy and accurate calibration
Design according to ASME BPE standard

Technical requirements:

Measuring task: pH
Process pressure: 0 to 16 bar (0 to 232 psi)
Max. process temperature: 40°C (104°F)
CIP/SIP: 130°C (266°F)
Density: 0.8 to 1.25 g/cm³

Analysis measurement in: Retentate conductivity

Endress+Hauser offers a suite of analytical instruments ideal for this stage.

Digital 4-electrode conductivity sensor Memosens CLS82E

Memosens 2.0 contacting conductivity sensor for hygienic applications in life sciences, food & bev

Alternatives:

Digital conductivity sensor Indumax CLS54D

Memosens toroidal conductivity sensor for hygienic and sterile applications

Conductivity compact device Smartec CLD134

Toroidal conductivity measuring system for hygienic and sterile applications

General Requirements:

High accuracy
Wide measurement range
Suitable for CIP/SIP
Fast response time
Design according to ASME BPE standard

Technical requirements:

Measuring task: Conductivity
Process pressure: 0 to 16 bar (0 to 232 psi)
Max. process temperature: 40°C (104°F)
CIP/SIP: 130°C (266°F)
Density: 0.8 to 1.25 g/cm³

Analysis measurement in: Retentate UV

Endress+Hauser offers a suite of analytical instruments ideal for this stage.

UV absorption sensor OUSAF44

Sensor for inline product quantification

General Requirements:

Fast response time
Cleanability (CIP/SIP), gap-free design
Fully self-drainable in horizontal installations
Design according to ASME BPE standard
Smallest hold-up volume

Technical requirements:

Measuring task: Concentration
Process pressure: 0 to 16 bar (0 to 232 psi)
Max. process temperature: 40°C (104°F)
CIP/SIP: 130°C (266°F)
Density: 0.8 to 1.25 g/cm³

Stainless steel process skid used in biopharmaceutical manufacturing

Key instrumentation challenges in the virus filtration process

Differential pressure as an indicator of fouling: Continuous virus filtration systems are particularly sensitive because prolonged operation increases the risk of pressure build-up and fouling. Variations in feed conditions can also increase system pressure.

Flow and flux stability as an indicator of process control: Virus filtration performance depends heavily on maintaining a defined flux through the membrane. Flow instability can affect residence time and filter loading.

Detecting filter fouling before failure: Unfortunately, there is rarely a direct measurement for the exact lifetime left in the virus filter. Fouling develops gradually and no single instrument directly measures membrane integrity during operation. This is why trend analytics are often more valuable than a single measurement.

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Micropilot FMR43 – radar sensor for hygienic processes

High performance sensor, especially compact and the perfect fit for fast changing level applications

Proline Promass P 100
Coriolis flowmeter

The specialist for life sciences with an ultra-compact transmitter

Digital pH sensor
Memosens CPS61E

Memosens 2.0 glass sensor for the food & beverage industry and for bioreactors in biotech industry

Digital 4-electrode conductivity sensor
Memosens CLS82E

Memosens 2.0 contacting conductivity sensor for hygienic applications in life sciences, food & bev

UV absorption sensor
OUSAF44

Sensor for inline product quantification

iTHERM ModuLine TM411
Hygienic modular thermometer

Metric RTD thermometer with or without thermowell for hygienic applications

Cerabar PMP43 – hygienic pressure transmitter

Particularly compact, highly reliable and the perfect fit for demanding hygienic applications

FAQ

Frequent questions on the virus filtration process

How does viral clearance by tangential flow?

Tangential flow filtration achieves viral clearance by passing a liquid feed parallel across the surface of a membrane rather than straight through it, using size exclusion and fluid shear to separate or retain viral particles.

What is viral clearance by tangential flow?

Viral clearance by tangential flow is a filtration method that removes or separates viruses from a liquid mixture. It uses tangential flow filtration, also known as cross-flow filtration, where the fluid flows parallel to the filter surface rather than straight through it.

How does virus filtration work in bioprocessing?

Virus filtration in bioprocessing uses specialized nanofilters to remove viral contaminants through size exclusion, multilayer trapping, and fluid dynamics. It acts as a final safety barrier in purifying therapeutic proteins like monoclonal antibodies.

What are the critical process parameters in viral clearance by tangential flow?

CPPs for viral clearance and processing via tangential flow filtration include transmembrane pressure, cross-flow velocity and molecular weight cut-off or pore size. Controlling these variables ensures high vector recovery while preventing membrane fouling.

Which measurements are needed to monitor viral clearance by tangential flow?

Monitoring viral clearance by tangential flow filtration requires measuring transmembrane pressure, cross-flow rate/velocity and virus titers to calculate the log reduction value.

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Key instrumentation challenges in the virus filtration process

Explore our innovations for your virus filtration process

Frequent questions on the virus filtration process

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Virus filtration (tangential flow filtration)

Key instrumentation challenges in the virus filtration process

Explore our innovations for your virus filtration process

Frequent questions on the virus filtration process

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