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Raman bio sleeve

Maintain sterility and spectral quality while reducing maintenance and cleaning burdens

Raman spectroscopy disposable bio sleeve for bioprocessing Raman bio multi optic, clamp, o-ring, and bio sleeve for single and multi-use bioprocessing Raman bio multi optics and bio sleeves (220 and 120 mm) with standard clamps for the Life Sciences Low background window design of a Raman spectroscopy probe window for the biopharmaceutical industry
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Low background window design of a Raman spectroscopy probe window for the biopharmaceutical industry
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Raman Rxn-10 probe with a bio multi optic in a bio sleeve in a table-top, single-use bioreactor
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Raman spectroscopy disposable bio sleeve for bioprocessing
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Raman bio multi optic, clamp, o-ring, and bio sleeve for single and multi-use bioprocessing
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Raman bio multi optics and bio sleeves (220 and 120 mm) with standard clamps for the Life Sciences
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Low background window design of a Raman spectroscopy probe window for the biopharmaceutical industry
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Raman Rxn-10 probe with a bio multi optic in a bio sleeve in a table-top, single-use bioreactor
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Raman spectroscopy calibration verification kit for bio multi and single use optic in Life Sciences
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Raman bio sleeve

Maintain sterility and spectral quality while reducing maintenance and cleaning burdens

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Benefits

  • Improved ease of use and reduced maintenance
  • Autoclavable, gamma sterilizable, and compatible with standard cleaning protocols
  • Simplified workflow for greater process efficiency – swap out probes mid-batch, use multiple sleeves in the same reactor for simplified redundancy, and calibrate / verify probes at any time
  • 120 mm version is compatible with Endress+Hauser flow assembly CYA680
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Integrated technologies

Raman spectroscopy - advanced optical analysis technology

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Raman bio sleeve

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Manufacturer's warranty

Engineered for confidence

Our instruments are designed for long‑lasting performance, precise measurement, and dependable operation in demanding industrial environments. Each product includes a standard manufacturer’s warranty that reflects our commitment to quality and to the trust you place in our solutions.

Should a warranty case occur, the device will be assessed and the applicable remedy will be provided in line with the warranty terms – helping ensure a reliable and efficient resolution and supporting continued operation of your measurement point.

Request for extended warranty

If you require extended warranty coverage, simply contact your local Endress+Hauser representative. Our experts will advise you on the available options to match your application and risk profile, helping you protect your investment, reduce unexpected repair costs, and ensure reliable long‑term operation beyond the manufacturer's warranty period.

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Warranty terms apply

The manufacturer's warranty and extended warranty are subject to specific conditions. For full details, please refer to the locally applicable General Terms and Conditions (GTC), which can be found on the respective country page of our website.

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Endress+Hauser’s qualified service engineers ensure your measurement devices are commissioned right the first time, delivering application‑aligned accuracy, regulatory compliance, and operational confidence from startup onwards, anywhere in the world.

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Technology

Raman spectroscopy - advanced optical analysis technology

Boost plant safety, ensure product quality, and optimize operations. Raman spectroscopy measures the composition and molecular structure of your samples from lab-to-process in real time.

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Product information

Raman spectroscopy disposable bio sleeve for bioprocessing
Raman bio sleeve
Specifications
Measuring / Application task Liquids, Bioprocessing

Measuring principle

Raman spectroscopy

Temperature


-30 to 150 °C / -22 to 302 °F

Sampling probe compatibility

Raman Rxn-10

Sampling optic compatibility

bio multi optic

Pressure

Max pressure: 13.8 barg / 200 psig

Wetted materials

Body: 316L stainless steel
Window: Proprietary material, optimized for bioprocesses
Surface finish: Ra 15 with Electropolish to ASME BPE SF4 finish
Adhesive: USP Class VI and ISO 10993 compatible

Immersible length

120 or 220 mm
4.73 or 8.67 inch

Immersible diameter

12 mm
0.48 inch

Sterilization method

Autoclave, gamma irradiation

Process connection

PG13.5
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Description

The bio sleeve is a critical consumable part for easy, real-time bioprocess measurements with maximum sterility and efficiency. It connects to a reusable, automatically aligned multi optic which pairs with an Rxn-10 probe. The system reduces maintenance and cross-contamination risk for reusable or single-use benchtop bioreactor setups.

Field of application
  • Benchtop bioreactors to measure glucose, lactate, amino acids, cell density, titer and more
  • Benchtop fermenters to measure glycerol, methanol, ethanol, sorbitol, biomass, and more
  • Use with flow assembly CYA680 for select downstream bioprocessing applications
Benefits
  • Improved ease of use and reduced maintenance
  • Autoclavable, gamma sterilizable, and compatible with standard cleaning protocols
  • Simplified workflow for greater process efficiency – swap out probes mid-batch, use multiple sleeves in the same reactor for simplified redundancy, and calibrate / verify probes at any time
  • 120 mm version is compatible with Endress+Hauser flow assembly CYA680
Downloads
Most downloaded
Technical Information (TI)
Multi optic calibration and verification kit Technical Information System design and specifications for the multi optic calibration
and verification kit
English version - 06/2023
Download
Technical Information (TI)
Accessory optics for the Rxn-10 probe Technical Information System design and specifications for Rxn-10 probe optics: Raman
immersion optics (KIO1), non-contact optics (KNCO1),
bIO-Optics (KLBIO1), bio multi optics (KRBMO), bio sleeves
(KRBSL), and Raman optic system for single use (KRSU1)
English version - 07/2026
Download
Technical Information (TI)
Rxn-10 Raman spectroscopic probe Technical Information System design and specifications for the Raman Rxn-10 probe
English version - 09/2025
Download
The CAD Drawings will be available after the configuration.
More options
Download page as PDF Search downloads by serial number
More options
Download page as PDF Search downloads by serial number
All downloads
45 Downloads
Technical Information (TI)
Multi optic calibration and verification kit Technical Information System design and specifications for the multi optic calibration
and verification kit
English version - 06/2023
Download
Technical Information (TI)
Accessory optics for the Rxn-10 probe Technical Information System design and specifications for Rxn-10 probe optics: Raman
immersion optics (KIO1), non-contact optics (KNCO1),
bIO-Optics (KLBIO1), bio multi optics (KRBMO), bio sleeves
(KRBSL), and Raman optic system for single use (KRSU1)
English version - 07/2026
Download
Technical Information (TI)
Rxn-10 Raman spectroscopic probe Technical Information System design and specifications for the Raman Rxn-10 probe
English version - 09/2025
Download
Operating Instruction (BA)
Accessory optics for the Rxn-10 probe Operating Instructions Commissioning, operation, and maintenance details for Rxn-10
probe optics: Raman immersion optics (KIO1), non-contact
optics (KNCO1), bIO-Optics (KLBIO1), bio multi optic
(KRBMO), bio sleeve (KRBSL), and Raman optic system for
single use (KRSU1)
English version - 06/2026
Download
Operating Instruction (BA)
Rxn-10 Raman spectroscopic probe Operating Instructions Commissioning, operation, and maintenance details
for the Raman Rxn-10 probe
English version - 09/2025
Download
Operating Instruction (BA)
Multi optic calibration and verification kit Operating Instructions Commissioning, operation, and maintenance details for the
multi optic calibration and verification kit
English version - 06/2023
Download
Short Instruction (KA)
Rxn-10 Raman spectroscopic probe Brief Operating Instructions Quick start guide for the Raman Rxn-10 probe
English version - 12/2024
Download
Short Instruction (KA)
Accessory Optics for the Rxn-10 Probe Brief Operating Instructions Quick start guide for Rxn-10 probe optics: Raman immersion optics
(KIO1), non-contact optics (KNCO1), bIO-Optics (KLBIO1), bio
multi optics (KRBMO), bio sleeves (KRBSL), and
Raman optic system for single use (KRSU1)
English version - 06/2026
Download
PU (Publication)
Top must-read Biopharma 4.0 articles - Stay informed about the latest research embracing Biopharma 4.0 principles A list of published technical articles related to Biopharma 4.0
topics with recommendations from Life Science industry experts
at Endress+Hauser.
English version - 06/2025
Download
PU (Publication)
Endress+Hauser - ライフサイエンス技術のワンストップパートナー Endress+Hauserが、ライフサイエンス分野の専門知識と、ラマン分
光システム（Raman Rxn2、Raman Rxn4、Rxn-10、Rxn-45、Rxn-46、
バイオマルチオプティックおよびスリーブ、フローフィル、フロー
ベンチ、シングルユース用Ramanオプティックシステム）や水質分
析センサ技術（Liquiline CM44P、CM442、OUSAF44、OUSBT66、
Memosens CPS61E、CLS82E、COS81E、CLS82E）などの信頼性の高い
インラインおよびリアルタイム測定技術によって、世界トップクラ
スのバイオ医薬品メーカーから信頼されている理由を強調したグラ
フィック。
Japanese version - 10/2024
Download
PU (Publication)
Biopharma 4.0 model graphic Graphic illustrating the core elements of Biopharma 4.0 including
product lifecycle stages, role of PAT/QbD, and 12 key advanced
technologies for scientists and process engineers in the Life
Sciences, applicable to Raman spectroscopy systems (Raman
Rxn2, Raman Rxn4, Rxn-10, Rxn-45, Rxn-46, bio multi optic and
sleeve, flow cell and flow bench, Raman optic system for single
use, and Raman calibration & verification kits).
English version - 05/2025
Download
PU (Publication)
Bioprocessing infrastructure readiness for online analytical instrumentation integration - Is your upstream operation ready for seamless deployment of an online Raman spectroscopy system? This self-assessment questionnaire helps pharmaceutical and API
manufacturers evaluate their readiness for implementing online
Raman spectroscopy. A simple scoring system identifies potential
infrastructure, integration, and process monitoring challenges, helping
teams assess deployment complexity and prepare for successful
real-time analytical monitoring.
English version - 08/2026
Download
PU (Publication)
Analytical costs, scale-up delays, and optimization potential in upstream bioprocessing - Is your upstream process costing more than you think? This self-assessment questionnaire helps bioprocessing teams evaluate
analytical costs and delays associated with scaling up from laboratory
development to production. A scoring system helps identify optimization
opportunities and assess the value of real-time monitoring using online
Raman spectroscopy.
English version - 08/2026
Download
PU (Publication)
効率的なバイオ医薬品の製品開発ライフサイクルのために拡張性を優先 この技術文書では、ライフサイエンス産業におけるバイオプロセス
の競争優位性としての拡張性の重要性と、Endress+Hauserの拡張性
のあるラマンシステム（Raman Rxn2、Raman Rxn4、Rxn-10、Rxn-45
、Rxn-46、バイオマルチオプティックおよびスリーブ、フローフィ
ル、フローベンチ、シングルユース用Ramanオプティックシステム）
、水質分析センサ技術、および水質分析製品ラインナップ
（LiquilineCM44P、CM442、OUSAF44、OUSBT66、Memosens CPS61E、
CLS82E、COS81E、CLS82E）について考察しています。
Japanese version - 10/2024
Download
PU (Publication)
ライフサイエンスにおけるラボからプロセスまでの監視と制御 バイオプロセスの物理的・化学的特性の信頼性の高い測定 この製品リストは、ライフサイエンス業界におけるバイオプロセス
用途向けに、光学分析および液体分析の両方から提供される分析機
器をまとめたものです。含まれる製品には、Raman Rxn2アナライザ
、Raman Rxn4アナライザ、Rxn-10プローブ、バイオマルチオプティ
ックおよびバイオスリーブ、ラマンフローアセンブリ、Rxn-45プロ
ーブ、Rxn-46プローブ、シングルユース向けラマンオプティックシ
ステム、Memosens CPS61E、Memosens COS81E、OUSBT66、Memosens
CPS77E、Memosens CLS82E、OUSAF44、Memosens CPS11E、Memosens
CLS16E、TOCアナライザーCA79、Liquiline変換器プラットフォーム
、およびMemobaseソフトウェアが含まれています。
Japanese version - 08/2025
Download
PU (Publication)
Raman spectroscopy in GMP environments This guide explains Raman spectroscopy implementation in
GMP-regulated pharmaceutical and biopharmaceutical
manufacturing, covering qualification, validation, data
integrity, supplier and user responsibilities, and
risk-based compliance approaches for process analytical
technology applications.
English version - 08/2026
Download
PU (Publication)
Biopharma 4.0 model graphic (full version) Expanded version of a graphic illustrating the core elements of
Biopharma 4.0 including product lifecycle stages, role of
PAT/QbD, and 12 key advanced technologies for scientists and
process engineers in the Life Sciences, applicable to Raman
spectroscopy systems (Raman Rxn2, Raman Rxn4, Rxn-10,
Rxn-45, Rxn-46, bio multi optic and sleeve, flow cell and flow
bench, Raman optic system for single use, and Raman calibration
& verification kits).
English version - 05/2025
Download
PU (Publication)
Prioritize scalability for an efficient biopharmaceutical product development lifecycle This technical paper studies the importance of scalability as a
competitive advantage in bioprocessing in the Life Science industry,
and Endress+Hauser's scalable Raman systems (Raman Rxn2,
Raman Rxn4, Rxn-10, Rxn-45, Rxn-46, bio multi optic and sleeve,
flow cell and flow bench, Raman optic system for single use) and
liquid analysis sensor technology and Liquid Analysis portfolio
(Liquiline CM44P, CM442 and OUSAF44, OUSBT66 and
Memosens CPS61E, CLS82E, COS81E, CLS82E).
Czech version - 09/2024
Download
PU (Publication)
Real-time analytical control of your API synthesis process - Is your API crystallization process truly under control between lab analyses? This self-assessment questionnaire helps API synthesis teams in the
Life Sciences industry identify analytical blind spots and assess the
value of real-time inline Raman spectroscopy for monitoring API
crystallization processes.
English version - 08/2026
Download
PU (Publication)
Analytical blind spots and contamination risks in upstream bioprocessing - Are your cell cultures truly under control between measurements? This self-assessment questionnaire helps cell culture and upstream
bioprocessing teams identify analytical blind spots, contamination
risks from manual sampling, and opportunities to improve process
control through real-time monitoring. A simple scoring system
highlights where online Raman spectroscopy may help improve data
quality, reduce risk, and support faster process decisions.
English version - 08/2026
Download
PU (Publication)
Prioritize scalability for an efficient biopharmaceutical product development lifecycle This technical paper studies the importance of scalability as a
competitive advantage in bioprocessing in the Life Science industry,
and Endress+Hauser's scalable Raman systems (Raman Rxn2,
Raman Rxn4, Rxn-10, Rxn-45, Rxn-46, bio multi optic and sleeve,
flow cell and flow bench, Raman optic system for single use) and
liquid analysis sensor technology and Liquid Analysis portfolio
(Liquiline CM44P, CM442 and OUSAF44, OUSBT66 and
Memosens CPS61E, CLS82E, COS81E, CLS82E).
English version - 06/2024
Download
PU (Publication)
The Biopharma 4.0 glossary - Test your Biopharma 4.0 IQ A list of definitions and sources for frequently used terms and
abbreviations in the biopharmaceutical industry related to
Biopharma 4.0.
English version - 06/2025
Download
PU (Publication)
Asset utilization and cost of non-conformance in API manufacturing - Are hidden analytical costs and process inefficiencies impacting your API production? This self-assessment questionnaire helps API and pharmaceutical
manufacturing teams identify the financial impact of analytical delays,
asset idle time, and batch nonconformities during multi-step synthesis
processes. A simple scoring system helps quantify optimization
opportunities and assess the potential value of real-time process
monitoring using online Raman spectroscopy to improve throughput,
reduce risk, and maximize asset utilization.
English version - 08/2026
Download
PU (Publication)
Process infrastructure readiness assessment for in-line Raman spectroscopy - Is your facility ready to integrate an in-line analytical monitoring system without major modifications? This self-assessment questionnaire helps pharmaceutical and API
manufacturing teams evaluate their readiness for deploying online
Raman spectroscopy and other real-time analytical monitoring
technologies. A simple scoring system highlights the maturity of
existing process infrastructure and helps estimate the effort
required to successfully implement real-time process analytics.
English version - 08/2026
Download

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Raman spectroscopy system bio multi optic
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Bioprocessing Raman spectroscopy calibration and verification kit for the Raman flow assembly
Raman calibration and verification kits

Everything needed to calibrate and verify your Raman analyzer system for lab-to-process scalability

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Raman spectroscopy disposable bio sleeve for bioprocessing
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Selection of compatible products

Raman spectroscopy system bio multi optic
Raman bio multi optic

Optimize spectral quality for bioprocess measurement

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Product picture Raman Rxn-10 probe on side aiming right
Raman Rxn-10 probe

A versatile probe for your Raman spectroscopy needs

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Bioprocessing Raman spectroscopy calibration and verification kit for the Raman flow assembly
Raman calibration and verification kits

Everything needed to calibrate and verify your Raman analyzer system for lab-to-process scalability

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