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Raman bIO-Optics

Continuous, inline, multi-component bioprocess measurement

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Raman bIO-Optics

Continuous, inline, multi-component bioprocess measurement

Get a quote
Office situation support
Have questions about this product?

Benefits

  • Immersion optics for multi-component bioprocess measurement
  • Compatible with standard bioreactor ports
  • Fixed-focus design
  • Available in 12 mm diameter with Pg 13.5 threaded connector
  • 120, 220, 320, or 420 mm lengths
  • Autoclavable

Integrated technologies

Raman spectroscopy - advanced optical analysis technology

Services and resources

FLEXible answers to individual needs
Current product

Raman bIO-Optics

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  • High-end products
  • Highly functional and convenient

What is FLEX?

FLEX selections
Technical excellence
Simplicity
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Fundamental selection Meet your basic measurement needs
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Lean selection Handle your core processes easily
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Extended selection Optimize your processes with innovative technologies
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Xpert selection Master your most challenging applications
Variable
Manufacturer's warranty

Engineered for confidence

Our instruments are designed for long‑lasting performance, precise measurement, and dependable operation in demanding industrial environments. Each product includes a standard manufacturer’s warranty that reflects our commitment to quality and to the trust you place in our solutions.

Should a warranty case occur, the device will be assessed and the applicable remedy will be provided in line with the warranty terms – helping ensure a reliable and efficient resolution and supporting continued operation of your measurement point.

Request for extended warranty

If you require extended warranty coverage, simply contact your local Endress+Hauser representative. Our experts will advise you on the available options to match your application and risk profile, helping you protect your investment, reduce unexpected repair costs, and ensure reliable long‑term operation beyond the manufacturer's warranty period.

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Warranty terms apply

The manufacturer's warranty and extended warranty are subject to specific conditions. For full details, please refer to the locally applicable General Terms and Conditions (GTC), which can be found on the respective country page of our website.

Services by your side

Right‑first‑time commissioning, worldwide

Endress+Hauser’s qualified service engineers ensure your measurement devices are commissioned right the first time, delivering application‑aligned accuracy, regulatory compliance, and operational confidence from startup onwards, anywhere in the world.

Remote support you can trust wherever you operate

With Endress+Hauser Smart Support, you benefit from faster issue resolution, higher uptime, reliable global expertise across the entire product lifecycle – and lasting peace of mind.

Committed to long‑term, sustainable performance

With deep field expertise, harmonized processes, and continuous monitoring, we accompany you with comprehensive service offerings – from initial start‑up through instrumentation maintenance to process optimization – as a true lifetime partner delivering improved outcomes.

For additional information, please contact your local Endress+Hauser representative.

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Personalized transaction space

Check prices and delivery times, save your favorite products, create quotes and place orders in just a few clicks and track deliveries at any time. With access to your complete order and quote history including all relevant documents you benefit from full transparency throughout the entire process.

Easy access to technical documentation

Select and download all technical documentation such as operating manuals, calibration certificates, approvals and CAD drawings conveniently bundled as a complete documentation package for your entire order or quote.

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My Endress+Hauser is your 24/7 connection to Endress+Hauser – in the office, in the field or on the go. It brings together transaction management, documentation and software downloads, knowledge base access, customer support, engineering tools and cloud‑based IIoT services helping you work easier, faster and more efficiently.

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Technology

Raman spectroscopy - advanced optical analysis technology

Boost plant safety, ensure product quality, and optimize operations. Raman spectroscopy measures the composition and molecular structure of your samples from lab-to-process in real time.

Product information

Product picture Raman bIO-Optics 120, 220, 320 side view aiming left with tags showing
Raman bIO-Optics
Specifications
Measuring / Application task Liquids
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Description

Raman bIO-Optics are versatile immersion optics used in conjunction with the Rxn-10 probehead and compatible with standard bioreactor ports. The fixed focus design provides long-term measurement stability along with superior signal performance, essential for transferable, high performance Raman-based bioprocess analysis. Available in industry standard lengths, Raman bIO-Optics are ideally suited for both glass and plastic benchtop bioreactor/fermenter applications requiring headplate entry.

Field of application
  • Cell culture: glucose, lactate, glutamine, amino acids, cell density, titer
  • Fermentation: glycerol, methanol, ethanol, sorbitol, biomass
  • Downstream: aggregation, protein crystallization, formula stability, product CQA, protein concentration, buffer excipients
Benefits
  • Immersion optics for multi-component bioprocess measurement
  • Compatible with standard bioreactor ports
  • Fixed-focus design
  • Available in 12 mm diameter with Pg 13.5 threaded connector
  • 120, 220, 320, or 420 mm lengths
  • Autoclavable
Downloads
Most downloaded
Technical Information (TI)
Accessory optics for the Rxn-10 probe Technical Information System design and specifications for Rxn-10 probe optics: Raman
immersion optics (KIO1), non-contact optics (KNCO1),
bIO-Optics (KLBIO1), bio multi optics (KRBMO), bio sleeves
(KRBSL), and Raman optic system for single use (KRSU1)
English version - 07/2026
Download
Technical Information (TI)
Rxn-10 Raman spectroscopic probe Technical Information System design and specifications for the Raman Rxn-10 probe
English version - 09/2025
Download
Operating Instruction (BA)
Accessory optics for the Rxn-10 probe Operating Instructions Commissioning, operation, and maintenance details for Rxn-10
probe optics: Raman immersion optics (KIO1), non-contact
optics (KNCO1), bIO-Optics (KLBIO1), bio multi optic
(KRBMO), bio sleeve (KRBSL), and Raman optic system for
single use (KRSU1)
English version - 06/2026
Download
The CAD Drawings will be available after the configuration.
All downloads
19 Downloads
Technical Information (TI)
Accessory optics for the Rxn-10 probe Technical Information System design and specifications for Rxn-10 probe optics: Raman
immersion optics (KIO1), non-contact optics (KNCO1),
bIO-Optics (KLBIO1), bio multi optics (KRBMO), bio sleeves
(KRBSL), and Raman optic system for single use (KRSU1)
English version - 07/2026
Download
Technical Information (TI)
Rxn-10 Raman spectroscopic probe Technical Information System design and specifications for the Raman Rxn-10 probe
English version - 09/2025
Download
Operating Instruction (BA)
Accessory optics for the Rxn-10 probe Operating Instructions Commissioning, operation, and maintenance details for Rxn-10
probe optics: Raman immersion optics (KIO1), non-contact
optics (KNCO1), bIO-Optics (KLBIO1), bio multi optic
(KRBMO), bio sleeve (KRBSL), and Raman optic system for
single use (KRSU1)
English version - 06/2026
Download
Operating Instruction (BA)
Rxn-10 Raman spectroscopic probe Operating Instructions Commissioning, operation, and maintenance details
for the Raman Rxn-10 probe
English version - 09/2025
Download
Short Instruction (KA)
Rxn-10 Raman spectroscopic probe Brief Operating Instructions Quick start guide for the Raman Rxn-10 probe
English version - 12/2024
Download
Short Instruction (KA)
Accessory Optics for the Rxn-10 Probe Brief Operating Instructions Quick start guide for Rxn-10 probe optics: Raman immersion optics
(KIO1), non-contact optics (KNCO1), bIO-Optics (KLBIO1), bio
multi optics (KRBMO), bio sleeves (KRBSL), and
Raman optic system for single use (KRSU1)
English version - 06/2026
Download
PU (Publication)
Top must-read Biopharma 4.0 articles - Stay informed about the latest research embracing Biopharma 4.0 principles A list of published technical articles related to Biopharma 4.0
topics with recommendations from Life Science industry experts
at Endress+Hauser.
English version - 06/2025
Download
PU (Publication)
Raman-Anwendungsleitfaden für die Life-Sciences-Industrie Ein Leitfaden zu unseren Anwendungshinweisen zur
Raman-Spektroskopie für die Life-Science-Industrie
(Raman Rxn2-Analysator, Raman Rxn4-Analysator,
Rxn-10-Sonde, Rxn-20-Sonde, Rxn-45-Sonde,
Rxn-46-Sonde und Zubehör für Sondenoptiken
(blO-Optic, Raman- Single Use-Optiksystem
/ SUB, Immersionsoptik, berührungslose Optik)
German version - 09/2025
Download
PU (Publication)
Raman application guide for the life science industry - Trusted composition analysis for the life sciences A guide to our Raman spectroscopy application notes for the
Life Science industry (featuring the Raman Rxn2 analyzer,
Raman Rxn4 analyzer, Rxn-10 probe, Rxn-20 probe, Rxn-45 probe,
Rxn-46 probe, and probe accessory optics (bIO-Optic, Raman single
use optic system / SUB, immersion optic, non-contact optic).
English version - 04/2022
Download
PU (Publication)
The Biopharma 4.0 glossary - Test your Biopharma 4.0 IQ A list of definitions and sources for frequently used terms and
abbreviations in the biopharmaceutical industry related to
Biopharma 4.0.
English version - 06/2025
Download
PU (Publication)
ライフサイエンス産業向けのラマンアプリケーションガイド -ライフサイエンスのための信頼できる組成分析 ライフサイエンス産業向けラマン分光法アプリケーションノート(
ラマンRxn2アナライザー、ラマンRxn4アナライザー、Rxn-10プロー
ブ、Rxn-20プローブ、Rxn-45プローブ、Rxn-46プローブ、プローブ
オプティックアクセサリ(bIOオプティック、シングルユース向け
ラマンオプティックシステム/SUB、浸漬オプティック、非接触オプ
ティック)。
Japanese version - 08/2024
Download
Innovation (IN)
バイオプロセスにおけるラマン技術 - 拡張性のあるin situバイオプロセス監視と高度なプロセス制御 Kaiserラマンテクノロジーを搭載した、バイオプロセス/バイオ医
薬品業界向けのラマン分光アナライザーとプローブ製品ラインナッ
プ(ラマンRxn2アナライザー、ラマンRxn4アナライザー、Rxn-10プ
ローブ、Rxn-45プローブ、Rxn-46プローブ、プローブオプティック
アクセサリ(bIOオプティック、シングルユース向けラマンオプテ
ィックシステム、バイオマルチオプティックおよびバイオスリーブ
と組合せ、ラマンフローアセンブリを含む)の概要パンフレット。
Japanese version - 08/2024
Download
Innovation (IN)
Raman technology in bioprocessing - Scalable in situ bioprocess monitoring enabling advanced process control An overview brochure about our Raman spectroscopy analyzer
and probe portfolio, powered by Kaiser Raman technology, for
the bioprocessing / biopharmaceutical industry (including the
Raman Rxn2 analyzer, Raman Rxn4 analyzer, Rxn-10 probe,
Rxn-45 probe, Rxn-46 probe, and probe accessory optics (bIO-Optic,
Raman single use optic system, bio multi optic with bio sleeve, and
Raman flow assembly), powered by Kaiser Raman technology.
English version - 06/2023
Download
Innovation (IN)
Raman spectrographic probes - Robust optical measurement of chemical composition An overview brochure about our Raman spectroscopy probe
portfolio including the Rxn-10 probe, Rxn-20 probe, Rxn-30 probe,
Rxn-40 probe, Rxn-41 probe, Rxn-45 probe, Rxn-46 probe, and
probe accessory optics (bIO-Optic, Raman single use optic system /
SUB, immersion optic , non-contact optic), powered by Kaiser Raman
technology.
English version - 10/2021
Download
Innovation (IN)
ラマン分光プローブ - 堅牢な分光分析による化学組成分析 ラマン分光法プローブ製品ラインナップに関する概要パンフレット
です。この製品ラインナップには、Rxn-10プローブ、Rxn-20プロー
ブ、Rxn-30プローブ、Rxn-40プローブ、Rxn-41プローブ、Rxn-45プ
ローブ、Rxn-46プローブ、およびプローブオプティクアクセサリ
(bIOオプティック、シングルユース向けラマンオプティックシス
テム/SUB、浸漬オプティック、非接触オプティック)が含まれてい
ます。これらはすべて、Kaiserラマンテクノロジーによって動作し
ます。
Japanese version - 06/2024
Download
Innovation (IN)
Raman-Sonden - Zuverlässige optische Analyse der chemischen Zusammensetzung Eine Übersichtsbroschüre über unser Raman-Spektroskopie-Sondenportfolio
einschließlich der Sonden Rxn-10, Rxn-20, Rxn-30,
Rxn-40, Rxn-41, Rxn-45, Rxn-46 und Sonden-Zubehöroptiken
(bIO-Optic, Raman-Singel-Use optiken/SUB,
Immersionsoptik, berührungslose Optik),
die auf der Kaiser Raman-Technologie basiert.
German version - 09/2025
Download
Innovation (IN)
Technologie Raman pour les bioprocédés Surveillance évolutive des bioprocédés in situ et contrôle
avancé des process
French version - 02/2024
Download
Innovation (IN)
Raman-Technologie in Bioprozessen Skalierbare in-situ Überwachung und
fortschrittliche Steuerung von Bioprozesse
German version - 08/2025
Download
White paper (WP)
Biopharma 4.0: Navigating the future of biomanufacturing A whitepaper about embracing the transformative impact of
Biopharma 4.0 technologies in a new era of biopharmaceutical
manufacturing (applicable to the Endress+Hauser Raman analyzer
and probe bioprocessing portfolio).
English version - 02/2025
Download

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