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Raman Rxn-46 probe

Raman interface adapted and optimized to fit the BioPAT® Spectro platform by Sartorius

Product picture Raman Rxn-46 probe front view Endress+Hauser Rxn-46 probe integrated with Ambr® by Sartorius Product picture Raman Rxn-46 probe installed with Biostat STR® Raman Rxn-46 calibration and verification kit
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Endress+Hauser Rxn-46 probe integrated with Ambr® by Sartorius
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Product picture Raman Rxn-46 probe installed with Biostat STR®
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Raman Rxn-46 calibration and verification kit
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Raman Rxn-46 probe

Raman interface adapted and optimized to fit the BioPAT® Spectro platform by Sartorius

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Benefits

  • Enables faster, easier, and more robust model building via integration with Ambr® 15 and Ambr® 250
  • Allows high-throughput process development which supports QbD
  • Provides a more efficient transfer to Biostat STR® for single-use manufacturing
  • Offers a scale-independent interface from 15 ml in the laboratory to 2000 L in the production suite
  • Requires no probe cleaning, sterilization, or frequent maintenance due to non-contact sampling
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Integrated technologies

Raman spectroscopy - advanced optical analysis technology

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Product Support Product documentation, troubleshooting articles, device details and more.
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Raman Rxn-46 probe

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Manufacturer's warranty

Engineered for confidence

Our instruments are designed for long‑lasting performance, precise measurement, and dependable operation in demanding industrial environments. Each product includes a standard manufacturer’s warranty that reflects our commitment to quality and to the trust you place in our solutions.

Should a warranty case occur, the device will be assessed and the applicable remedy will be provided in line with the warranty terms – helping ensure a reliable and efficient resolution and supporting continued operation of your measurement point.

Request for extended warranty

If you require extended warranty coverage, simply contact your local Endress+Hauser representative. Our experts will advise you on the available options to match your application and risk profile, helping you protect your investment, reduce unexpected repair costs, and ensure reliable long‑term operation beyond the manufacturer's warranty period.

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Warranty terms apply

The manufacturer's warranty and extended warranty are subject to specific conditions. For full details, please refer to the locally applicable General Terms and Conditions (GTC), which can be found on the respective country page of our website.

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Right‑first‑time commissioning, worldwide

Endress+Hauser’s qualified service engineers ensure your measurement devices are commissioned right the first time, delivering application‑aligned accuracy, regulatory compliance, and operational confidence from startup onwards, anywhere in the world.

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With Endress+Hauser Smart Support, you benefit from faster issue resolution, higher uptime, reliable global expertise across the entire product lifecycle – and lasting peace of mind.

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With deep field expertise, harmonized processes, and continuous monitoring, we accompany you with comprehensive service offerings – from initial start‑up through instrumentation maintenance to process optimization – as a true lifetime partner delivering improved outcomes.

For additional information, please contact your local Endress+Hauser representative.

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Technology

Raman spectroscopy - advanced optical analysis technology

Boost plant safety, ensure product quality, and optimize operations. Raman spectroscopy measures the composition and molecular structure of your samples from lab-to-process in real time.

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Product information

Product picture Raman Rxn-46 probe front view
Raman Rxn-46 probe
Specifications
Measuring / Application task Liquids

Laser wavelength


785 nm

Sample interface

Temperature: probe is non-contact; operating temp: 10 to 50 °C / 50 to 122 °F

Measuring principle

Raman spectroscopy

Laser wavelength


785 nm

Spectral coverage

Probe spectral coverage is limited by the coverage of the analyzer being used.

Maximum laser power into probehead (mW)

< 499

Sample interface

Temperature: probe is non-contact; operating temp: 10 to 50 °C / 50 to 122 °F

Wetted materials

Body: n/a
Window: n/a
Process connection: Sartorius BioPAT® Spectro
Surface finish: n/a
Adhesive: n/a

Fiber optic cable

Cable sold separately
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Description

The union between our Raman analyzers equipped with Rxn-46 bioprocess probe technology and the BioPAT® Spectro platform by Sartorius offers the market an ideal interface to high-throughput development through single-use commercial manufacturing. Our Raman bioprocessing probe technology has been adapted to fit Sartorius’s BioPAT® Spectro platform​, utilizing the same probe design for Ambr® 15, Ambr® 250, & Biostat STR® bioreactors​.

Field of application
  • Cell culture: glucose, lactate, amino acids, cell density, titer, and more
Benefits
  • Enables faster, easier, and more robust model building via integration with Ambr® 15 and Ambr® 250
  • Allows high-throughput process development which supports QbD
  • Provides a more efficient transfer to Biostat STR® for single-use manufacturing
  • Offers a scale-independent interface from 15 ml in the laboratory to 2000 L in the production suite
  • Requires no probe cleaning, sterilization, or frequent maintenance due to non-contact sampling
Downloads
Most downloaded
Technical Information (TI)
Rxn-46 Raman spectroscopic probe Technical Information System design and specifications for the Raman Rxn-46 probe
English version - 10/2025
Download
PU (Publication)
Raman-Anwendungsleitfaden für die Life-Sciences-Industrie Ein Leitfaden zu unseren Anwendungshinweisen zur
Raman-Spektroskopie für die Life-Science-Industrie
(Raman Rxn2-Analysator, Raman Rxn4-Analysator,
Rxn-10-Sonde, Rxn-20-Sonde, Rxn-45-Sonde,
Rxn-46-Sonde und Zubehör für Sondenoptiken
(blO-Optic, Raman- Single Use-Optiksystem
/ SUB, Immersionsoptik, berührungslose Optik)
German version - 09/2025
Download
Technical Information (TI)
Raman Rxn-46 calibration and verification kit Technical Information System design and specifications for the Raman Rxn-46
calibration and verification kit
English version - 01/2024
Download
The CAD Drawings will be available after the configuration.
More options
Download page as PDF Search downloads by serial number
More options
Download page as PDF Search downloads by serial number
All downloads
55 Downloads
Technical Information (TI)
Most downloaded
Rxn-46 Raman spectroscopic probe Technical Information System design and specifications for the Raman Rxn-46 probe
English version - 10/2025
Download
Technical Information (TI)
Raman Rxn-46 calibration and verification kit Technical Information System design and specifications for the Raman Rxn-46
calibration and verification kit
English version - 01/2024
Download
Operating Instruction (BA)
Rxn-46 Raman spectroscopic probe Operating Instructions Commissioning, operation, and maintenance details
for the Raman Rxn-46 probe
English version - 10/2025
Download
Operating Instruction (BA)
Raman Rxn-46 calibration and verification kit Operating Instructions Commissioning, operation, and maintenance details for the
Raman Rxn-46 calibration and verification kit
English version - 01/2024
Download
Short Instruction (KA)
Rxn-46 Raman spectroscopic probe Brief Operating Instructions Quick start guide for the Raman Rxn-46 probe
English version - 12/2024
Download
PU (Publication)
Top must-read Biopharma 4.0 articles - Stay informed about the latest research embracing Biopharma 4.0 principles A list of published technical articles related to Biopharma 4.0
topics with recommendations from Life Science industry experts
at Endress+Hauser.
English version - 06/2025
Download
PU (Publication)
Biopharma 4.0 model graphic Graphic illustrating the core elements of Biopharma 4.0 including
product lifecycle stages, role of PAT/QbD, and 12 key advanced
technologies for scientists and process engineers in the Life
Sciences, applicable to Raman spectroscopy systems (Raman
Rxn2, Raman Rxn4, Rxn-10, Rxn-45, Rxn-46, bio multi optic and
sleeve, flow cell and flow bench, Raman optic system for single
use, and Raman calibration & verification kits).
English version - 05/2025
Download
PU (Publication)
Endress+Hauser - ライフサイエンス技術のワンストップパートナー Endress+Hauserが、ライフサイエンス分野の専門知識と、ラマン分
光システム（Raman Rxn2、Raman Rxn4、Rxn-10、Rxn-45、Rxn-46、
バイオマルチオプティックおよびスリーブ、フローフィル、フロー
ベンチ、シングルユース用Ramanオプティックシステム）や水質分
析センサ技術（Liquiline CM44P、CM442、OUSAF44、OUSBT66、
Memosens CPS61E、CLS82E、COS81E、CLS82E）などの信頼性の高い
インラインおよびリアルタイム測定技術によって、世界トップクラ
スのバイオ医薬品メーカーから信頼されている理由を強調したグラ
フィック。
Japanese version - 10/2024
Download
PU (Publication)
Raman spectroscopy in GMP environments This guide explains Raman spectroscopy implementation in
GMP-regulated pharmaceutical and biopharmaceutical
manufacturing, covering qualification, validation, data
integrity, supplier and user responsibilities, and
risk-based compliance approaches for process analytical
technology applications.
English version - 08/2026
Download
PU (Publication)
Raman application guide for the life science industry - Trusted composition analysis for the life sciences A guide to our Raman spectroscopy application notes for the
Life Science industry (featuring the Raman Rxn2 analyzer,
Raman Rxn4 analyzer, Rxn-10 probe, Rxn-20 probe, Rxn-45 probe,
Rxn-46 probe, and probe accessory optics (bIO-Optic, Raman single
use optic system / SUB, immersion optic, non-contact optic).
English version - 04/2022
Download
PU (Publication)
Kaiser Raman technology and Sartorius BioPAT Spectro® collaboration Q&A - Scalable, real-time bioprocess monitoring solutions A Q&A about how our Raman spectroscopy analyzer systems
(including the Raman Rxn2 analyzer, Raman Rxn4 analyzer,
and Rxn-46 probe), powered by Kaiser Raman technology, integrates
with the Sartorius BioPAT Spectro platform (Ambr and biostat STR) for
high throughput and single use (SUB) bioprocessing in the
biopharmaceutical life science industry.
English version - 12/2021
Download
PU (Publication)
Biopharma 4.0 model graphic (full version) Expanded version of a graphic illustrating the core elements of
Biopharma 4.0 including product lifecycle stages, role of
PAT/QbD, and 12 key advanced technologies for scientists and
process engineers in the Life Sciences, applicable to Raman
spectroscopy systems (Raman Rxn2, Raman Rxn4, Rxn-10,
Rxn-45, Rxn-46, bio multi optic and sleeve, flow cell and flow
bench, Raman optic system for single use, and Raman calibration
& verification kits).
English version - 05/2025
Download
PU (Publication)
効率的なバイオ医薬品の製品開発ライフサイクルのために拡張性を優先 この技術文書では、ライフサイエンス産業におけるバイオプロセス
の競争優位性としての拡張性の重要性と、Endress+Hauserの拡張性
のあるラマンシステム（Raman Rxn2、Raman Rxn4、Rxn-10、Rxn-45
、Rxn-46、バイオマルチオプティックおよびスリーブ、フローフィ
ル、フローベンチ、シングルユース用Ramanオプティックシステム）
、水質分析センサ技術、および水質分析製品ラインナップ
（LiquilineCM44P、CM442、OUSAF44、OUSBT66、Memosens CPS61E、
CLS82E、COS81E、CLS82E）について考察しています。
Japanese version - 10/2024
Download
PU (Publication)
ライフサイエンスにおけるラボからプロセスまでの監視と制御 バイオプロセスの物理的・化学的特性の信頼性の高い測定 この製品リストは、ライフサイエンス業界におけるバイオプロセス
用途向けに、光学分析および液体分析の両方から提供される分析機
器をまとめたものです。含まれる製品には、Raman Rxn2アナライザ
、Raman Rxn4アナライザ、Rxn-10プローブ、バイオマルチオプティ
ックおよびバイオスリーブ、ラマンフローアセンブリ、Rxn-45プロ
ーブ、Rxn-46プローブ、シングルユース向けラマンオプティックシ
ステム、Memosens CPS61E、Memosens COS81E、OUSBT66、Memosens
CPS77E、Memosens CLS82E、OUSAF44、Memosens CPS11E、Memosens
CLS16E、TOCアナライザーCA79、Liquiline変換器プラットフォーム
、およびMemobaseソフトウェアが含まれています。
Japanese version - 08/2025
Download
PU (Publication)
Prioritize scalability for an efficient biopharmaceutical product development lifecycle This technical paper studies the importance of scalability as a
competitive advantage in bioprocessing in the Life Science industry,
and Endress+Hauser's scalable Raman systems (Raman Rxn2,
Raman Rxn4, Rxn-10, Rxn-45, Rxn-46, bio multi optic and sleeve,
flow cell and flow bench, Raman optic system for single use) and
liquid analysis sensor technology and Liquid Analysis portfolio
(Liquiline CM44P, CM442 and OUSAF44, OUSBT66 and
Memosens CPS61E, CLS82E, COS81E, CLS82E).
Czech version - 09/2024
Download
PU (Publication)
Most downloaded
Raman-Anwendungsleitfaden für die Life-Sciences-Industrie Ein Leitfaden zu unseren Anwendungshinweisen zur
Raman-Spektroskopie für die Life-Science-Industrie
(Raman Rxn2-Analysator, Raman Rxn4-Analysator,
Rxn-10-Sonde, Rxn-20-Sonde, Rxn-45-Sonde,
Rxn-46-Sonde und Zubehör für Sondenoptiken
(blO-Optic, Raman- Single Use-Optiksystem
/ SUB, Immersionsoptik, berührungslose Optik)
German version - 09/2025
Download
PU (Publication)
Prioritize scalability for an efficient biopharmaceutical product development lifecycle This technical paper studies the importance of scalability as a
competitive advantage in bioprocessing in the Life Science industry,
and Endress+Hauser's scalable Raman systems (Raman Rxn2,
Raman Rxn4, Rxn-10, Rxn-45, Rxn-46, bio multi optic and sleeve,
flow cell and flow bench, Raman optic system for single use) and
liquid analysis sensor technology and Liquid Analysis portfolio
(Liquiline CM44P, CM442 and OUSAF44, OUSBT66 and
Memosens CPS61E, CLS82E, COS81E, CLS82E).
English version - 06/2024
Download
PU (Publication)
The Biopharma 4.0 glossary - Test your Biopharma 4.0 IQ A list of definitions and sources for frequently used terms and
abbreviations in the biopharmaceutical industry related to
Biopharma 4.0.
English version - 06/2025
Download
PU (Publication)
KaiserラマンテクノロジーとSartorius BioPAT Spectro® の コラボレーションQ&A 拡張性のあるリアルタイムバイオプロセス監視ソリューション このQ&Aでは、Kaiser Ramanテクノロジーを搭載したラマン分光計
システム（Raman Rxn2アナライザ、Raman Rxn4アナライザ、Rxn-46
プローブを含む）が、バイオ医薬品ライフサイエンス業界における
ハイスループットおよびシングルユース（SUB）バイオプロセスに
対応するSartorius社のBioPAT Spectroプラットフォーム（Ambrお
よびBiostat STR）とどのように統合されるかについて説明してい
ます。
Japanese version - 12/2025
Download
PU (Publication)
ライフサイエンス産業向けのラマンアプリケーションガイド -ライフサイエンスのための信頼できる組成分析 ライフサイエンス産業向けラマン分光法アプリケーションノート（
ラマンRxn2アナライザー、ラマンRxn4アナライザー、Rxn-10プロー
ブ、Rxn-20プローブ、Rxn-45プローブ、Rxn-46プローブ、プローブ
オプティックアクセサリ（bIOオプティック、シングルユース向け
ラマンオプティックシステム/SUB、浸漬オプティック、非接触オプ
ティック）。
Japanese version - 08/2024
Download
PU (Publication)
ラマン校正および検証キット ラボからプロセスへの拡張性を実現するラマン分光計システムの校 正と検証のために必要なものすべて バイオマルチオプティック／シングルユースオプティックおよびラ
マンフローアセンブリ（フローベンチとフローセルを含む）用のラ
マン校正および検証キットの概要です。これらのキットは、Kaiser
ラマンテクノロジーを搭載したRxn-10プローブおよびRaman Rxn2 /
Rxn4アナライザーと併用し、バイオプロセスの上流および下流工
程で使用されます。
Japanese version - 08/2025
Download
PU (Publication)
Lab-to-process monitoring & control in Life Sciences - Reliable measurement of bioprocess physical and chemical properties A combined product list of analysis offerings from both Optical Analysis
and LIquid Analysis for bioprocessing applications in the life science
industry (including Raman Rxn2 analyzer, Raman Rxn4 analyzer,
Rxn-10 probe, bio multi optic and bio sleeve, Raman flow assembly,
Rxn-45 probe, Rxn-46 probe, Raman optic system for single use,
Memosens CPS61E, Memosens COS81E, OUSBT66, Memosens CPS61E,
Memosens CPS77E, Memosens CLS82E, OUSAF44, Memosens CPS11E,
Memosens CLS16E, TOC Analyzer CA79, Liquiline transmitter platform, and
Memobase software).
English version - 04/2024
Download
PU (Publication)
Raman calibration and verification kits - Everything needed to calibrate and verify your Raman analyzer system for lab-to-process scalability An overview of the Raman calibration and verification kits for
the bio multi optic / single use optic and the Raman flow assembly
(includes the flow bench and flow cell). These kits are to be used in
conjunction with the Rxn-10 probe and Raman Rxn2 / Rxn4 analyzer
for upstream and downstream bioprocessing (powered by Kaiser
Raman technology).
English version - 12/2023
Download
PU (Publication)
Endress+Hauser - your one-source Life Sciences technology partner Graphic highlighting why Endress+Hauser is trusted by the
world's top biopharmaceutical manufacturers for its Life
Sciences expertise and reliable inline, real-time measurement
technologies like Raman spectroscopy systems (Raman Rxn2,
Raman Rxn4, Rxn-10, Rxn-45, Rxn-46, bio multi optic and sleeve,
flow cell and flow bench, Raman optic system for single use) and
liquid analysis sensor technology (Liquiline CM44P, CM442 and
OUSAF44, OUSBT66 and Memosens CPS61E, CLS82E, COS81E,
CLS82E).
English version - 06/2024
Download

Back
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Product picture Raman Rxn-46 probe front view
Raman Rxn-46 probe

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Spare parts and accessories

further parts
further parts

Rxn-46 Light Shield

further parts
further parts
Order code 70187818
further parts
further parts

Raman Rxn-46 KR46

further parts
further parts
Order code KR46-
Spare parts & accessories
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further parts
further parts

Rxn-46 Light Shield

Rxn-46 Light Shield

further parts
further parts
Order code 70187818
further parts
further parts

Raman Rxn-46 KR46

Raman Rxn-46 KR46

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further parts
Order code KR46-
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